IFIH1 and interstitial lung disease: Prognostic factors were analyzed using χ<sup>2</sup> test, Log-rank test, COX and logistic regression analysis.<h4>Results</h4>In this cohort, 125 anti-MDA5 + CADM-ILD patients exhibited a rapidly progressive interstitial lung disease (RPILD) incidence of 37.6%, and an overall mortality rate of 24.8%.