Notably, a patient with microphthalmia syndromic 6 (P85) exhibited rapid increases in GV and HtSDS (GV = 10.4 cm/year, ΔHtSDS = 0.99); conversely, one patient with 3M syndrome (P13) demonstrated slower increases in GV and HtSDS (GV = 7.4 cm/year, ΔHtSDS = 0.24), indicating less effective GH therapy. This evidence concerns the gene GH1 and microphthalmia with brain and digit anomalies.