In particular, the rs4644, encoding for a proline to histidine substitution at codon 64 of gal-3 [P64 > H64], was associated with variable risks of breast (Balan et al., 2008), prostate, cervical (Meyer et al., 2013; Fang et al., 2017), and differentiated thyroid carcinoma (DTC) (de Boer et al., 2012; Song et al., 2014). This evidence concerns the gene LGALS3 and differentiated thyroid carcinoma.