IGHE and Alzheimer disease: Furthermore, in a randomized, double-blind, placebo-controlled study enrolling 70 patients with AD aged 6 to 12 years, the administration of melatonin (6 mg daily) demonstrated to improve SCORAD (p = 0.007), objective SCORAD (p = 0.001), serum total IgE levels (p = 0.005) and Children’s Sleep Habits Questionnaire scores (p = 0.006) at 6 weeks (40).