The mouse FH model induced by murine hepatitis virus strain-3 (MHV-3) has been widely employed in FH investigations, given the presence of sinusoidal thrombosis, hepatocellular necrosis, and elevated levels of fibrinogen-like protein 2 (Pope et al. 1995; Marsden et al. 2003; Levy et al. 1981). This evidence concerns the gene FGL2 and familial hyperaldosteronism.