In addition to autophagy, cellular pyroptosis, iron death, and necrotic apoptosis can exert synergistic anti-tumor immune responses, and tumor cells can release signals to recruit CD8+ T cells through cellular pyroptosis, while on the other hand, CD8+ T cells induce tumor cell pyroptosis through the GSDME-GZMB axis (129). The gene discussed is GZMB; the disease is neoplasm.