MTOR and Parkinson disease: In this regard, studies have demonstrated an alteration of mTOR signaling in PD where there is an overactivation of mTOR which in turn reduces neuronal autophagy and promotes the accumulation of α-syn (Ghavami et al., 2014; Recasens et al., 2014; Gao et al., 2015; Wong and Krainc, 2017; Zhang Z. et al., 2021).