Nasal mucosal inflammation and the associated allergic rhinitis (AR) symptoms are induced by allergic reactions which are largely mediated by histamine (HIS), a major chemical mediator, and its interaction with histamine receptor 1 (H1R) (Powell et al., 2007; Mizuguchi et al., 2012); the activation of H1R by HIS results in the symptoms of AR (Mizuguchi et al., 2012). This evidence concerns the gene HRH1 and allergic rhinitis.