Fahey CC et al. reported a case of metastatic penile squamous cell carcinoma responsive to EV (Fahey et al., 2023); this case supports the use of ADCs, including EV, in squamous cell carcinomas, including penile cancers, due to the observed high expression of Nectin-4 (Fahey et al., 2023; Grass et al., 2023). Here, NECTIN4 is linked to squamous cell carcinoma.