GPT and Hyponatremia: One mefunidone-treated subject (11.1%) in the B2 cohort and one mefunidone-treated subject (11.1%) in the B3 cohort had six TEAEs of moderate degree (hypertriglyceridemia, alanine aminotransferase increase, and dizziness in the B2 cohort and tonsillitis, hyponatremia, and alanine aminotransferase increase in the B3 cohort).