Being a nuclear stain, it is easy to interpret, shows high concordance with morphologic blasts, and identifies populations seen by current markers of immaturity (CD34 and CD117) in most cases, suggesting the potential utility of ERG in difficult-to-diagnose AML. Further larger studies, looking into the specificity, precision, and accuracy of ERG, are needed. Here, CD34 is linked to acute myeloid leukemia.