The Cp+/SST+ and GCG+/SST + bi-hormonal cells were reported in zebrafish models of diabetes (Carril Pardo et al., 2022; Singh et al., 2022), lineage tracing experiments in mice (Gribben et al., 2021; Perez-Frances et al., 2022), and during beta cell differentiation from human stem cells (Leavens et al., 2021). This evidence concerns the gene CP and diabetes mellitus.