Presence of somatic mutations inPBRM1, BAP1, SETD2, KDM5C, ATM, MTOR, orPTEN genes in 451 TCGA ccRCC patients was associated with a significantly shorter DFS compared to those with unaltered tumors (p<0.001; q=0.01) (Figure 3). The gene discussed is KDM5C; the disease is nonpapillary renal cell carcinoma.