Presence of somatic mutations inPBRM1, BAP1, SETD2, KDM5C, ATM, MTOR, orPTEN genes in 451 TCGA ccRCC patients was associated with a significantly shorter disease-free survival (DFS) compared to those with unaltered tumors (q=0.01). The gene discussed is SETD2; the disease is nonpapillary renal cell carcinoma.