Presence of somatic mutations inPBRM1, BAP1, SETD2, KDM5C, ATM, MTOR, orPTEN genes in 451 TCGA ccRCC patients was associated with a significantly shorter DFS compared to those with unaltered tumors (p<0.001; q=0.01) (Figure 3). This evidence concerns the gene ATM and nonpapillary renal cell carcinoma.