HSPB1 and head and neck squamous cell carcinoma: Interestingly, the circRNA circGNG7 has been shown to interfere with the phosphorylation of HSP27 at Ser78 and Ser82 in head and neck squamous cell carcinoma (HNSCC), thus impeding its phosphorylation within malignant signaling pathways and potentially reducing chemoresistance in HNSCC (53).