TXNIP and Ewing sarcoma: Moreover, from a mechanistic standpoint, SOX6, a transcriptional target of the EWS-FLI1 oncoprotein, was shown to increase ROS and oxidative stress in Ewing sarcoma cells via upregulation of thioredoxin interacting protein (TXNIP), an inhibitor of thioredoxin and inducer of ROS (24, 25).