SARS-CoV-2 enters cells by binding to the host cellular receptor Angiotensin-Converting Enzyme 2 (ACE2) via its spike protein (Song et al., 2018; Zhao et al., 2020; Piplani et al., 2021; Jackson et al., 2022), and typically causes a lower respiratory tract infection, which can progress to severe acute respiratory syndrome and potentially multiple organ failure (Ganji et al., 2020; Tu et al., 2020; Tao et al., 2021; Yang et al., 2021). The gene discussed is ACE2; the disease is Recurrent lower respiratory tract infections.