Through various physiological mechanisms such as increasing cardiac contractility, improving cardiac output, and increasing the release of nitric oxide by endothelial cells, aerobic exercise can improve endothelial function, increase vascular elasticity, reduce the risk of atherosclerosis and inflammation, decrease vascular inflammatory responses and endothelial cell damage, thus lowering CRP levels (Green et al., 1985). The gene discussed is CRP; the disease is atherosclerosis.