Adipocytes tend to enhance glycolysis in the TME, as in renal clear cell carcinoma, where the browning of adipocytes is activated by parathyroid hormone-related proteins secreted by cancer cells, leading to the production of excess lactate (Wei et al., 2021), which is taken up and utilized by cancer cells as an energy source (Micallef et al., 2021). Here, PTHLH is linked to cancer.