PDHA1 and neoplasm: Another study indicated that AMPK-mediated phosphorylation of the pyruvate dehydrogenase complex (PDHc) catalytic subunit (PDHA) S295 during tumor metastasis restored PDHc activity through spatial competition for inhibition of PDK-mediated suppression of PDHA S293 phosphorylation, promoted a shift in cellular metabolism from glycolysis to OXPHOS, and enhanced metabolic adaptation in metastatic cells (Cai et al., 2020).