In osteosarcoma, the lnc-FGD5-AS1 is upregulated in osteosarcoma cells resistant to doxorubicin, and knockdown of its expression attenuates the chemoresistance to DOX by WNT5A-driven autophagy through miRNA-154-5p sponging (Fei et al., 2022). Here, FGD5 is linked to osteosarcoma.