The lncRNA FAL1, mainly derived from exosomal secretion by CAF, significantly inhibits autophagy induced by oxaliplatin and promotes oxaliplatin chemoresistance in CRC by acting as a scaffold for Beclin1 and TRIM3 to promote the polyubiquitylation of Beclin1 and its degradation (Zhu et al., 2023). This evidence concerns the gene BECN1 and colorectal carcinoma.