Steatohepatitis- associated circRNA ATP5B Regulator (SCAR), another mitochondria-encoded circRNA, binds to ATP5B directly to close mPTP (mitochondrial permeability transition pore), subsequently inhibits the output of mitochondrial ROS and finally prevents the hyperactivation of NASH fibroblasts [22]. The gene discussed is ATP5F1B; the disease is metabolic dysfunction-associated steatohepatitis.