HSPA1B (OR 2.41E-03, 95% CI 3.42E-04–1.70E-02), LY6G6D (OR 2.88E-03, 95% CI 2.73E-04–3.03E-02), BTN3A1 (OR 2.96E-03, 95% CI 2.63E-04 -3.33E-02), SFTA2 (OR 0.08, 95% CI 0.02–0.26), HSPA1L (OR 0.31, 95% CI 0.17–0.56), and VARS1 (OR 0.27, 95% CI 0.14–0.53) were observed to be negatively correlated with SS risk. This evidence concerns the gene VARS1 and synovial sarcoma.