TNFAIP3 and systemic lupus erythematosus: Notably, our study found that the top single nucleotide polymorphism (SNP) associated with SS located in TNFAIP3 was rs5029939, which is similar to previous findings that this SNP has been associated with various autoimmune diseases, including SLE, systemic sclerosis, and other autoimmune disorders (24–26).