Although influenza vaccination has proven to decrease hospitalization rates for pneumonia patients (29), and immunization against Spn has greatly reduced the incidence of invasive pneumococcal disease (30, 31), the vaccines for Spn and IAV offer protection against single infections however (32, 33), they have shown limited protection against co-infection in mice (34–36). The gene discussed is SPN; the disease is susceptibility to pneumonia measurement.