Interestingly, however, strains vary in their ability to develop anaphylaxis in response to the same antigen, and in some cases, NOD mice showed much greater susceptibility to developing anaphylaxis than common mouse strains, including B6 and BALB/c mice (43, 57), and even diabetes-resistant NOR mice that share the same MHC class II (57). Here, HLA-C is linked to anaphylaxis.