Our results indicate that a lack of duodenal KCNK16 expression may play a role in CIE pathogenesis, but it is also possible that the differential expression was due to breed differences, as our control population were all beagles and the CIE dogs consisted of 4 non-beagle purebred dogs. Here, KCNK16 is linked to congenital non-bullous ichthyosiform erythroderma.