This study was aimed at investigating (1) the expressing effects of obesity on serum RvE1 and chemerin levels, (2) the browning effects of RvE1 and chemerin on different adipose tissues, (3) the effects of RvE1 and chemerin on metabolic homeostasis, and (4) the mechanisms underlying how RvE1 and chemerin differentially regulate the development of beige adipocyte. The gene discussed is RARRES2; the disease is obesity due to melanocortin 4 receptor deficiency.