The association of RvE1 with obesity and its associated metabolic diseases, such as type 2 diabetes, was thought to be mediated by RvE1 or its precursor omega-3-PUFAs increasing adiponectin [34,35], but whether and how RvE1 is directly involved in metabolic homeostasis is unknown. Here, ADIPOQ is linked to obesity due to melanocortin 4 receptor deficiency.