The association of RvE1 with obesity and its associated metabolic diseases, such as type 2 diabetes, was thought to be mediated by RvE1 or its precursor omega-3-PUFAs increasing adiponectin [34,35], but whether and how RvE1 is directly involved in metabolic homeostasis is unknown. The gene discussed is ADIPOQ; the disease is type 2 diabetes mellitus.