This study was aimed at investigating (1) the expressing effects of obesity on serum RvE1 and chemerin levels, (2) the browning effects of RvE1 and chemerin on different adipose tissues, (3) the effects of RvE1 and chemerin on metabolic homeostasis, and (4) the mechanisms underlying how RvE1 and chemerin differentially regulate the development of beige adipocyte. This evidence concerns the gene RARRES2 and Obesity.