UCP1 and Obesity: To identify whether RvE1 improves the metabolic homeostasis against obesity via inducing the biogenesis of beige fat, RvE1 injected i.p. into WT mice or Ucp1−/− mice was found to alleviate the growth of body weight (Fig. 4a) during the HFD feeding despite maintaining comparable levels of food intake (Fig. S5a), which was dependent on UCP1.