PINK1 and non-small cell lung carcinoma: We further tested the effect of gefitinib on mitophagy in NSCLC cells, and our data showed that gefitinib significantly increased the mitophagy signal, which could be suppressed by PINK1 knockdown in A549 cells (Figs. 2c, d and S1a), indicating that gefitinib may widely enhance mitophagy driven by PINK1 in different types of cells.