By promoting the expression of autophagy-related genes Beclin-1 and Atg16 and activating the NOD2/Beclin-1 pathway, the autophagy of IELs can be enhanced, the inflammatory response of intestinal mucosal epithelium can be reduced, and the energy balance and cell homeostasis of intestinal tissue during ischemia can be maintained, thereby improving ALI. This evidence concerns the gene BECN1 and ischemia.