First, BS patients who have been reported to having pulmonary lesions with NOD2 mutation were a 23-years-old male with amino acid substitution Glu498Gly (not R334Q, R334W and L489F) (6), a six-teen-years-old male with R334 Q (3), a two-years-old and 7 months boy with pulmonary hemorrhage due to bronchial granuloma with the R334Q, a two-years-old boy with R334W and a nineteen-year-old male of this presenting with M513T. Here, NOD2 is linked to Pulmonary hemorrhage.