In vivo,melanoma-bearing mice treated with these micelles exhibited an 8-fold increasein boron accumulation in tumor tissues versus those treated with BPA, leading toprolonged tumor growth delay (5.4 days with micelles versus 3.3 days with BPA).Moreover, combining BNCT with anti-PD-L1 immunotherapy further extended thetumor growth delay to 6.6 days, and enhanced T-cell infiltration and activationat tumor sites, thereby indicating a boosted immune response. The gene discussed is CD274; the disease is melanoma.