In this study, we found that the oxidative stress, iron homeostasis and ferroptosis related proteins such as ferritins, heme oxygenase (HMOX1), tumor necrosis factor receptor-associated protein 1 (TRAP1) and catalase (CAT) were affected visibly after the addition of Si-IONPs both in tumor and normal cells (Figure 3). The gene discussed is HMOX1; the disease is neoplasm.