IL6 and Fabry disease: In addition, it has been demonstrated that increased levels of pro-inflammatory cytokines such as tumour necrosis factor 1&2, interleukin 6 and matrix metalloprotease (MMP) are seen with increasing severity of cardiac involvement in FD associated with LVH and HFpEF (54, 55) and has differed between FD and healthy volunteers as well as treated FD and non-treated FD.