It has been reported that Lactobacillus can prevent and treat obesity by regulating gut microbiota and intestinal permeability, improving insulin resistance, reducing low‐grade systemic inflammation caused by a high‐fat diet, activating brown fat, and regulating the expression of genes related to fat (Cani et al., 2007; Kang & Cai, 2018; Tenorio‐Jiménez et al., 2020). Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.