Acosta et al. demonstrated that in rats with cerebral ischemia, intravenous human bone marrow stromal cells (hBMSCs) rapidly migrated to the spleen and reduced the levels of TNF-α in the spleen, as well as reduced infarct volume and inflammatory response in infarct area (Acosta et al., 2015). The gene discussed is TNF; the disease is Cerebral ischemia.