Lipocalin-2 is a novel adipokine which has been shown to relate to the level of inflammation in diseases and therefore linked to obesity and insulin resistance [14] Correlation between lipocalin-2 and vascular endothelial growth factor has been found in patients with proliferative diabetes retinopathy [15] and to retinopathy in patients with diabetes and overweight/obesity [16]. This evidence concerns the gene LCN2 and obesity due to melanocortin 4 receptor deficiency.