An insightful study highlighted a direct role of rs339331 in regulating RFX6 expression and the involvement of androgen signaling in modulating the effects of rs339331/6q22 on PCa risk.[34] Despite these advancements, yet whether specific interactions between the inherited rs339331/6q22 allele and prostate‐lineage AR signaling in PCa progression remain uncertain. This evidence concerns the gene AR and posterior cortical atrophy.