The interplay among chromatin, gene regulatory elements, and transcription factors is crucial in gene expression regulation.[41] Single nucleotide polymorphism (SNP) variants identified via GWAS are key in modulating tumor‐specific cis‐regulatory elements.[42] In a comprehensive Phenome‐Wide Association Analysis (PheWAS) using data from the FinnGen cohort (n = 377277),[43] rs339331 at the RFX6/6q22 locus demonstrated the highest association with PCa among 2272 disease endpoints (Figure 1a). Here, RFX6 is linked to posterior cortical atrophy.