Considering the pivotal role of AR in PCa, especially its notable enrichment at the rs339331 locus, we delved into its interplay with RFX6.[44, 45] Utilizing chromatin immunoprecipitation allele‐specific quantitative PCR (ChIP‐AS‐qPCR) in VCaP cells, we confirmed significant AR recruitment to the PCa risk‐associated T allele of rs339331 upon exposure to dihydrotestosterone (DHT) (Figure 1c). This evidence concerns the gene AR and posterior cortical atrophy.