Our previous research identified the rs339331 variant at a conserved, functional regulatory element, characterized by the binding of transcription factor HOXB13, FOXA1, and AR in the PCa cell line.[33] Further analysis using human tissue ChIP‐seq data[36] corroborated the extensive recruitment of AR at the rs339331 enhancer unique in tumors (Figure 1b), indicating that the germline variant rs339331 converges on an epigenetically reprogrammed AR binding site over human prostate tumorigenesis. Here, HOXB13 is linked to male reproductive organ cancer.