AR and posterior cortical atrophy: A nonmutational epigenetically gained binding site of AR, a vital ligand‐dependent transcription factor within the steroid hormone receptor family, plays a critical role in regulating epithelial differentiation and cell proliferation, processes fundamental prostate development.[35, 36, 72, 73] This study uncovers a reprogrammed AR binding site at the 6q22 locus in PCa tumors, specifically linked to the rs339331 risk allele.[24, 33] The chromatin occupancy of AR at the rs339331 enhancer and its consequential impact on RFX6 expression shed light on the pivotal role of RFX6 in PCa progression.