Considering the extensive reprogramming of AR cistromes observed in PCa development, as highlighted in several groundbreaking studies,[35, 36, 37, 38, 39, 40] we hypothesize that AR signaling is critical in gene regulatory mechanisms underpinning PCa susceptibility, which is likely instrumental in linking the rs339331/RFX6/6q22 locus with PCa risk and progression. The gene discussed is AR; the disease is posterior cortical atrophy.