CHD4 and cancer: Abnormal expression of RFX6 selectively modulates HOXA10 expression, mirroring the gene regulatory specificity seen in the activation of CHD4 by the transcription factor ZNF410.[74] The HOX gene family member HOXA10 is linked to various cancers,[65, 75, 76, 77, 78] with its overexpression associated with adverse outcomes in PCa as described above.