Within the IEI population, individuals with defects in genes including AIRE (autoimmune regulator), IRF7 (interferon regulatory factor 7), and IFNAR1/2 (interferon-α/β receptor) had significantly higher COVID-19 case fatality rates, clearly demonstrating that genetics can adversely impact patient outcomes to SARS-CoV-2 infection [3]. The gene discussed is IRF7; the disease is COVID-19.