IFNAR1 and COVID-19: Within the IEI population, individuals with defects in genes including AIRE (autoimmune regulator), IRF7 (interferon regulatory factor 7), and IFNAR1/2 (interferon-α/β receptor) had significantly higher COVID-19 case fatality rates, clearly demonstrating that genetics can adversely impact patient outcomes to SARS-CoV-2 infection [3].