Moreover, in the Lewis lung carcinoma model, vaccination using an amino-rich FN nanoplatform loaded with tumor antigens and immunostimulatory CpG ODNs efficiently increases the CD3+CD8+, CD3−CD8+, and CD11b+CD80+ cell populations in the tumors, suggesting the alteration of the tumor microenvironment from cold to hot tumors. Here, CD8A is linked to neoplasm.