PROS1 and infection: Moreover, SARS2-S (SARS-RBD) mRNA induced potent and high-titer neutralizing antibodies, being able to potently neutralize infection with pseudotyped SARS-CoV encoding the S protein of an ancestral Tor2 strain, and effective neutralizing antibodies, which were able to neutralize infection of pseudotyped SARS-CoV-2 encoding the S protein of the ancestral strain (Figure 2h,i).