Comparison between the transcriptomic profiles of LAIV and TIV influenza vaccines and a live attenuated yellow fever vaccine [16,22] in human PBMCs, either isolated from the blood of vaccinees or stimulated in vitro with these vaccines, revealed that IRF7, OAS and MX1 were commonly induced by yellow fever and LAIV influenza vaccines and that the overexpression of type I IFN-related genes correlated with the magnitude of antibody responses to influenza and yellow fever vaccines [17]. The gene discussed is SMOC1; the disease is viral infectious disease.