As a major comorbidity, the patient in 1985 had a non-A non-B acute hepatitis, followed by a diagnosis of a genotype 1a chronic hepatis C (likewise his partner, with high viral load and IL-28b genotype C/T), which evolved to well-compensated cirrhosis [on average, Child–Pugh score: A5, model for end-stage liver disease-sodium (MELD Na) score: 7]. Here, IFNL3 is linked to Cirrhosis.