Liu et al. examined the mRNA and protein expression levels of CtIp in a HepG2 hepatocellular carcinoma cell line stably expressing HBx, and the results showed that the cell line was blocked in the G2/M phase of the cell cycle, and HBx down-regulated both CtIP protein expression level and mRNA expression level [100]. The gene discussed is RBBP8; the disease is hepatocellular carcinoma.