Meanwhile, CtBP is highly homologous to NAD-dependent D2-hydroxyacid dehydrogenases (D2-HDHs), and the experimental results of Balasubramanian et al. demonstrated that NADH induced a conformational change in CtBP, which enhanced the interaction of CtBP with E1A, suggesting that intracellular levels of NADH during viral infections can recruit CtBP to influence the E1A activity [87,88]. The gene discussed is CTBP1; the disease is viral infectious disease.