MPC1 and melanoma: The experimental data of Deng et al. showed that CtBP1 directly binds to and transcriptionally represses the promoters of melanoma cell-associated genes (pyruvate carrier 1 and 2 genes, MPC1 and MPC2), leading to an increase in the level of free NADH in the cell membrane and nucleus, and promoting the proliferation and migration of melanoma cells [34,35].