Here, we show CMV-induced dysregulation of the critical placental and neuro-developmental pathways, DYRK (DYRK1A, DYRK1B) and SHH (Gli2, Rb, Ulk3, and Shh), utilizing NHA cells to model the CMV infection of human astrocytes. The gene discussed is DYRK1B; the disease is cytomegalovirus infection.