GSDME and infection: Although we did not identify an effect of GSDMD or GSDME in virus replication, we did observe an increase in the release of infectious virus particles at late time points during infection in BEAS-2B cells when cells were treated with pan-caspase inhibitor z-VAD (Figure 5A,B), which suggests that caspase-mediated cell death could be a mechanism to limit virus replication and spread.