The key components of the IFN-I signaling pathway in tumor cells, such as cytoplasmic protein kinase dsRNA activation (PKR), retinoic acid inducible gene I (RIG-I), interferon regulatory factors (IRFs), and cell surface IFN-I α receptors (IFNAR), may be downregulated, which prevents the normal IFN response after NDV infection, leading to viral replication and spread within cells [2,31,32,33]. The gene discussed is EIF2AK2; the disease is neoplasm.