Intriguingly, while UL138 expression reduced IFNB1 and CXCL10 accumulation downstream of cGAS-STING-TBK1 [38], it has also been reported to enhance the expression of some interferon stimulated genes (ISGs) at late times during productive infection [104], presumably by promoting the activation of STAT1 [105]. This evidence concerns the gene TBK1 and infection.