Taken together, these data suggest that the role in promoting IFNB1 and VPA-responsive IE gene expression downstream of cGAS/STING during HCMV infection is specific to TBK1 and that IKKε may instead restrict viral gene expression during HCMV infection of incompletely differentiated myeloid cells. The gene discussed is IKBKE; the disease is cytomegalovirus infection.