The significant expression of angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine subtypes 2/4 (TMPRSS) on the lining of the small intestine’s mucosa links acute SARS-CoV-2 infection with gastrointestinal symptoms such as nausea, vomiting, diarrhea, and abdominal pain, while long term reported symptoms are appetite loss, weight loss, and irritable bowel syndrome, albeit with varying prevalence rates in the context of post-acute sequelae of SARS-CoV-2 infection (PASC) [27,28,29,30]. This evidence concerns the gene ACE2 and long COVID-19.