Moreover, using an independent cohort of FACS-sorted CD4+ T cells obtained from Belgian CD patients (Bioproject: PRJEB32332) and using our own RNA-seq analysis, we further strengthen the associations of PLCB1, TLR3, HDAC9, CD8B, and CRTAM genes in anti-TNFα response. Here, PLCB1 is linked to Cowden disease.