NFKB1 and colorectal carcinoma: Several cellular signaling pathways that regulate cell proliferation, differentiation, apoptosis, and survival are involved in CRC onset, such as epidermal growth factor receptor (EGFR)/mitogen-activated protein kinase (MAPK), wingless-related integration site (Wnt)/β-catenin, phosphoinositide 3-kinase (PI3K), transforming growth factor-β (TGF)-β, neurogenic locus notch homolog protein (Notch), and nuclear factor (NF)-κB [3].