Other important targets of SIRT3 activity are glutamate dehydrogenase (GDH) [33], involved in amino acid oxidation, and the transcriptional factor forkhead box O3 (FOXO3a), which increases the levels of manganese-dependent superoxide dismutase (MnSOD), reducing the levels of ROS [34], involved in cancer transformation. This evidence concerns the gene FOXO3 and cancer.