A total of 16,876 lncRNAs and 19,938 mRNAs were identified in the existing transcripts, along with the expression of related genes, including 19 genes involved in the regulation of cuproptosis (NFE2L2, NLRP3, ATP7B, ATP7A, SLC31A1, FDX1, LIAS, LIPT1, LIPT2, DLD, DLAT, PDHA1, PDHB, MTF1, GLS, CDKN2A, DBT, GCSH, and DLST) in patients with ccRCC. This evidence concerns the gene NLRP3 and nonpapillary renal cell carcinoma.